A comparison between capillary and venous blood international normalized ratio determinations in a portable prothrombin time device

被引：18

作者：

van den Besselaar, AMHP ^{[1
]}

Meeuwisse-Braun, J ^{[1
]}

Schaefer-van Mansfeld, H ^{[1
]}

van Rijn, C ^{[1
]}

Witteveen, E ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Ctr Hemostasis & Thrombosis Res, Dept Hematol, NL-2300 RC Leiden, Netherlands

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2000年 / 11卷 / 06期

关键词：

capillary blood; prothrombin time; oral anticoagulants;

D O I：

10.1097/00001721-200009000-00008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The CoaguChek(R) PT system is a portable point-of-care device for prothrombin time testing that can be used with capillary and venous whole blood. This system had been calibrated by the manufacturer in terms of the international normalized ratio (INR) for monitoring oral anticoagulant therapy. The purpose of the present study was to compare capillary blood with venous blood INRs from healthy volunteers and patients treated with oral anticoagulants using the same CoaguChek(R) PT system. Two different CoaguChek(R) PT strip formulations [international sensitivity index (ISI), 1.5 and 1.1] were used in separate test series. The differences between capillary and venous blood INRs were statistically significant (P < 0.001) but the magnitude of the differences was small. The mean relative deviations of the INR were 5.8 and 2.8% for the strips with ISI 1.5 and 1.1, respectively. These deviations are clinically acceptable. It is concluded that capillary blood can be replaced by venous blood for the calibration of the CoaguChek(R) PT system. Blood Coagul Fibrinolysis 11:559-562 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：559 / 562

页数：4

共 13 条

[1] Precision of patients' measurements of the international normalized ratio (INR) using a patient operated whole blood home coagulometer [J].