The Adenomatous Polyposis coli protein:: The achilles heel of the gut epithelium

被引：177

作者：

Näthke, IS ^{[1
]}

机构：

[1] Univ Dundee, Dundee DD1 5EH, Scotland

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2004年 / 20卷

关键词：

colon; cancer; migration; cytoskeleton; Wnt;

D O I：

10.1146/annurev.cellbio.20.012103.094541

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of beta-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis. The gut epithelium is uniquely dependent on an intricate balance between a number of fundamental cellular processes including migration, differentiation, adhesion, apoptosis, and mitosis. In this review, I discuss the molecular mechanisms that govern the various functions of APC and their relationship to the role of APC in colon cancer.

引用

收藏

页码：337 / 366

页数：30

相关论文

共 157 条

[71] TRANSGENIC MOUSE MODELS THAT EXPLORE THE MULTISTEP HYPOTHESIS OF INTESTINAL NEOPLASIA [J].

KIM, SH ;

ROTH, KA ;

MOSER, AR ;

GORDON, JI .

JOURNAL OF CELL BIOLOGY, 1993, 123 (04) :877-893

[72] Lessons from hereditary colorectal cancer [J].

Kinzler, KW ;

Vogelstein, B .

CELL, 1996, 87 (02) :159-170

[73] IDENTIFICATION OF FAP LOCUS GENES FROM CHROMOSOME-5Q21 [J].

KINZLER, KW ;

NILBERT, MC ;

SU, LK ;

VOGELSTEIN, B ;

BRYAN, TM ;

LEVY, DB ;

SMITH, KJ ;

PREISINGER, AC ;

HEDGE, P ;

MCKECHNIE, D ;

FINNIEAR, R ;

MARKHAM, A ;

GROFFEN, J ;

BOGUSKI, MS ;

ALTSCHUL, SF ;

HORII, A ;

ANDO, H ;

MIYOSHI, Y ;

MIKI, Y ;

NISHISHO, I ;

NAKAMURA, Y .

SCIENCE, 1991, 253 (5020) :661-665

[74] Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis [J].

Kirchner, T ;

Müuller, S ;

Hattori, T ;

Mukaisyo, K ;

Papadopoulos, T ;

Brabletz, T ;

Jung, A .

VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 2001, 439 (04) :512-522

[75] Spindle asymmetry: a compass for the cell [J].

Kusch, J ;

Liakopoulos, D ;

Barral, Y .

TRENDS IN CELL BIOLOGY, 2003, 13 (11) :562-569

[76] The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation:: a new facet to Knudson's 'two-hit' hypothesis [J].

Lamlum, H ;

Ilyas, M ;

Rowan, A ;

Clark, S ;

Johnson, V ;

Bell, J ;

Frayling, I ;

Efstathiou, J ;

Pack, K ;

Payne, S ;

Roylance, R ;

Gorman, P ;

Sheer, D ;

Neale, K ;

Phillips, R ;

Talbot, I ;

Bodmer, W ;

Tomlinson, I .

NATURE MEDICINE, 1999, 5 (09) :1071-1075

[77] Migrating colonic crypt epithelial cells: primary targets for transformation [J].

Lamprecht, SA ;

Lipkin, M .

CARCINOGENESIS, 2002, 23 (11) :1777-1780

[78] The roles of APC and axin derived from experimental and theoretical analysis of the Wnt pathway [J].

Lee, E ;

Salic, A ;

Krüger, R ;

Heinrich, R ;

Kirschner, MW .

PLOS BIOLOGY, 2003, 1 (01) :116-132

[79] Asymmetric loading of Kar9 onto spindle poles and microtubules ensures proper spindle alignment [J].

Liakopoulos, D ;

Kusch, J ;

Grava, S ;

Vogel, J ;

Barral, Y .

CELL, 2003, 112 (04) :561-574

[80] GlobPlot: exploring protein sequences for globularity and disorder [J].

Linding, R ;

Russell, RB ;

Neduva, V ;

Gibson, TJ .

NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3701-3708

← 3 4 5 6 7 8 9 10 11 12 →