Posttranscriptional orchestration of an anti-apoptotic program by HuR

被引：201

作者：

Abdelmohsen, Kotb ^{[1
]}

Lal, Ashish ^{[1
]}

Kim, Hyeon Ho ^{[1
]}

Gorospe, Myriam ^{[1
]}

机构：

[1] NIA, IRP, Cellular & Mol Biol Lab, NIH, Baltimore, MD USA

来源：

CELL CYCLE | 2007年 / 6卷 / 11期

关键词：

mRNA-binding protein; mRNA turnover; translational control; ELAV; SIRT1; ProT alpha; Bcl-2; Mcl-1;

D O I：

10.4161/cc.6.11.4299

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The RNA-binding protein HuR can stabilize and/ or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents. Here, we discuss emerging evidence that HuR elicits a broad anti-apoptotic function through its influence on the expression of multiple target mRNAs. HuR was previously shown to bind to the mRNA encoding the apoptosome inhibitor prothymosin a (ProT alpha) and enhanced its translation and cytoplasmic abundance. More recently, HuR was shown to increase the stability of a target mRNA encoding the pro-survival deacety lase SIRT1. The discovery that HuR likewise binds to and promotes the expression of mRNAs encoding Bcl-2 and Mcl-1, two major anti-apoptotic effectors, strongly supports HuR's role as a key upstream coordinator of a constitutive pro-survival program.

引用

页码：1288 / 1292

页数：5

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