Cytoprotection against oxidative stress and the regulation of glutathione synthesis

被引:106
作者
Dickinson, DA
Moellering, DR
Iles, KE
Patel, RP
Levonen, AL
Wigley, A
Darley-Usmar, VM
Forman, HJ [1 ]
机构
[1] Univ Alabama, Ctr Free Rad Biol, Sch Publ Hlth, Birmingham, AL 35294 USA
[2] Univ Alabama, Dept Environm Hlth Sci, Sch Publ Hlth, Birmingham, AL 35294 USA
[3] Univ Alabama, Sch Med, Dept Pathol, Birmingham, AL 35294 USA
关键词
DMNQ; 4-hydroxy-2-nonenal; GCLC; GCS; nitric oxide; oxidized low density lipoprotein;
D O I
10.1515/BC.2003.061
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adaptation to oxidative and nitrosative stress occurs in cells first exposed to a nontoxic stress, resulting in the ability to tolerate a toxic challenge of the same or a related oxidant. Adaptation is observed in a wide variety of cells including endothelial cells on exposure to nitric oxide or oxidized lipids, and lung epithelial cells exposed to air-borne pollutants and toxicants. This acquired characteristic has been related to the regulation of a family of stress responding proteins including those that control the synthesis of the intracellular antioxidant glutathione. The focus of this article, which includes a review of recent results along with new data, is the regulation and signaling of glutathione biosynthesis, especially those relating to adaptive mechanisms. These concepts are illustrated with examples using nitric oxide and oxidized low density lipoprotein mediated adaptation to oxidative stress. These data are discussed in the context of other adaptive mechanisms relating to glutathione synthesis including those from dietary constituents such as curcumin.
引用
收藏
页码:527 / 537
页数:11
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