Which transposable elements are active in the human genome?

被引：332

作者：

Mills, Ryan E.

Bennett, E. Andrew

Iskow, Rebecca C.

Devine, Scott E. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Ctr Bioinformat, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Genet & Mol Biol Grad Program, Atlanta, GA 30322 USA

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 04期

关键词：

D O I：

10.1016/j.tig.2007.02.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although a large proportion (44%) of the human genome is occupied by transposons and transposon-like repetitive elements, only a small proportion (< 0.05%) of these elements remain active today. Recent evidence indicates that similar to 35-40 subfamilies of Alu, L1 and SVA elements (and possibly HERV-K elements) remain actively mobile in the human genome. These active transposons are of great interest because they continue to produce genetic diversity in human populations and also cause human diseases by integrating into genes. In this review, we examine these active human transposons and explore mechanistic factors that influence their mobilization.

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页码：183 / 191

页数：9

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