Phosphoinositides specify polarity during epithelial organ development

被引：64

作者：

Comer, Frank I. ^{[1
]}

Parent, Carole A. ^{[1
]}

机构：

[1] NCI, Cellular & Mol Biol Lab, Canc Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2007年 / 128卷 / 02期

关键词：

D O I：

10.1016/j.cell.2007.01.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a three-dimensional model of epithelial morphogenesis, Martin-Belmonte et al. (2007) report that the phosphatase PTEN and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P-2] regulate the GTPase Cdc42 and the kinase aPKC to generate the apical plasma membrane domain and maintain apical-basolateral polarity.

引用

页码：239 / 240

页数：2

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