Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system

被引：50

作者：

Griffiths-Jones, Charlotte M. ^{[1
]}

Hopkin, Mark D. ^{[1
]}

Jonsson, Daniel ^{[1
]}

Ley, Steven V. ^{[1
]}

Tapolczay, David J. ^{[1
]}

Vickerstaffe, Emma ^{[1
]}

Ladlow, Mark ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, GlaxoSmithKline Cambridge Technol Ctr, Cambridge CB2 1EW, England

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2007年 / 9卷 / 03期

关键词：

D O I：

10.1021/cc060152b

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A fully automated flow-through process for the production of secondary sulfonamides is presented. Primary sulfonamides were monoalkylated using a two-step "catch and release" protocol to generate library products of high purity. The automated flow synthesis platform incorporates four independent reactor columns and is able to perform automated column regeneration. A 48-member sulfonamide library was prepared as two 24-member sublibraries, affording library compounds in good yields and high purities without the need for further column chromatographic purification.

引用

页码：422 / 430

页数：9

共 45 条

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