Playing hide and seek with mammalian meiotic crossover hotspots

被引：48

作者：

Buard, Jerome ^{[1
]}

de Massy, Bernard ^{[1
]}

机构：

[1] Inst Human Genet, UPR1142, CNRS, F-34396 Montpellier 5, France

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 06期

关键词：

D O I：

10.1016/j.tig.2007.03.014

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Crossovers (COs) are essential for meiosis and contribute to genome diversity by promoting the reassociation of alleles, and thus improve the efficiency of selection. COs are not randomly distributed but are found at specific regions, or CO hotspots. Recent results have revealed the historical recombination rates and the distribution of hotspots across the human genome. Surprisingly, CO hotspots are highly dynamic, as shown by differences in activity between individuals, populations and closely related species. We propose a role for DNA methylation in preventing the formation of COs, a regulation that might explain, in part, the correlation between recombination rates and GC content in mammals.

引用

页码：301 / 309

页数：9

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