Photoacoustic ophthalmoscopy for in vivo retinal imaging

被引：215

作者：

Jiao, Shuliang ^{[1
]}

Jiang, Minshan ^{[1
]}

Hu, Jianming ^{[1
]}

Fawzi, Amani ^{[1
]}

Zhou, Qifa ^{[2
]}

Shung, K. Kirk ^{[2
]}

Puliafito, Carmen A. ^{[1
]}

Zhang, Hao F. ^{[3
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA

[2] Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90033 USA

[3] Univ Wisconsin, Dept Elect Engn & Comp Sci, Milwaukee, WI 53201 USA

来源：

OPTICS EXPRESS | 2010年 / 18卷 / 04期

基金：

美国国家卫生研究院;

关键词：

OPTICAL COHERENCE TOMOGRAPHY; SCANNING LASER OPHTHALMOSCOPE; HIGH-RESOLUTION; DIABETIC-RETINOPATHY; FUNDUS PHOTOGRAPHY; MICROSCOPY;

D O I：

10.1364/OE.18.003967

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We have developed a non-invasive photoacoustic ophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high speed. For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT). By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously. The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo. (C) 2010 Optical Society of America

引用

页码：3967 / 3972

页数：6

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