The regulatory role of Vα14 NKT cells in innate and acquired immune response

被引：553

作者：

Taniguchi, M

Harada, M

Kojo, S

Nakayama, T

Wakao, H

机构：

[1] Chiba Univ, RIKEN, Res Ctr Allergy & Immunol, Lab Immune Regulat,Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Grad Sch Med, Dept Mol Immunol, Chiba 2608670, Japan

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2003年 / 21卷

关键词：

alpha-galactosylceramide; V alpha 14 NKT cell-deficient mice; GM-CSF receptor; gene rearrangement; regulation of immune response; innate immunity;

D O I：

10.1146/annurev.immunol.21.120601.141057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel lymphocyte lineage, Valpha 14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha 14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha 14 NKT cells helped elucidate the remarkable functional diversity of Valpha 14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.

引用

收藏

页码：483 / 513

页数：33

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