The regulatory role of Vα14 NKT cells in innate and acquired immune response

被引：555

作者：

Taniguchi, M

Harada, M

Kojo, S

Nakayama, T

Wakao, H

机构：

[1] Chiba Univ, RIKEN, Res Ctr Allergy & Immunol, Lab Immune Regulat,Chuo Ku, Chiba 2608670, Japan

[2] Chiba Univ, Grad Sch Med, Dept Mol Immunol, Chiba 2608670, Japan

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2003年 / 21卷

关键词：

alpha-galactosylceramide; V alpha 14 NKT cell-deficient mice; GM-CSF receptor; gene rearrangement; regulation of immune response; innate immunity;

D O I：

10.1146/annurev.immunol.21.120601.141057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel lymphocyte lineage, Valpha 14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha 14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha 14 NKT cells helped elucidate the remarkable functional diversity of Valpha 14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.

引用

页码：483 / 513

页数：33

共 148 条

[61]

Kawagoshi Y, 1998, WORLD J MICROB BIOT, V14, P95

[62] Monocyte chemoattractant protein-1-dependent increase of Vα14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection [J].

Kawakami, K ;

Kinjo, Y ;

Uezu, K ;

Yara, S ;

Miyagi, K ;

Koguchi, Y ;

Nakayama, T ;

Taniguchi, M ;

Saito, A .

JOURNAL OF IMMUNOLOGY, 2001, 167 (11) :6525-6532

[63] Activation of Vα14+ natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans [J].

Kawakami, K ;

Kinjo, Y ;

Yara, S ;

Koguchi, Y ;

Uezu, K ;

Nakayama, T ;

Taniguchi, M ;

Saito, A .

INFECTION AND IMMUNITY, 2001, 69 (01) :213-220

[64]

Kawano T, 1999, CANCER RES, V59, P5102

[65] CD1d-restricted and TCR-mediated activation of V(alpha)14 NKT cells by glycosylceramides [J].

Kawano, T ;

Cui, JQ ;

Koezuka, Y ;

Toura, I ;

Kaneko, Y ;

Motoki, K ;

Ueno, H ;

Nakagawa, R ;

Sato, H ;

Kondo, E ;

Koseki, H ;

Taniguchi, M .

SCIENCE, 1997, 278 (5343) :1626-1629

[66] A novel recognition motif of human NKT antigen receptor for a glycolipid ligand [J].

Kawano, T ;

Tanaka, Y ;

Shimizu, E ;

Kaneko, Y ;

Kamata, N ;

Sato, H ;

Osada, H ;

Sekiya, S ;

Nakayama, T ;

Taniguchi, M .

INTERNATIONAL IMMUNOLOGY, 1999, 11 (06) :881-887

[67]

KIMURA M, 1983, EVOLUTION GENES PROT, V11, P208

[68] The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells [J].

Kitamura, H ;

Iwakabe, K ;

Yahata, T ;

Nishimura, S ;

Ohta, A ;

Ohmi, Y ;

Sato, M ;

Takeda, K ;

Okumura, K ;

van Kaer, L ;

Kawano, T ;

Taniguchi, M ;

Nishimura, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) :1121-1127

[69] α-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells [J].

Kitamura, H ;

Ohta, A ;

Sekimoto, M ;

Sato, M ;

Iwakabe, K ;

Nakui, M ;

Yahata, T ;

Meng, HX ;

Koda, T ;

Nishimura, S ;

Kawano, T ;

Taniguchi, M ;

Nishimura, T .

CELLULAR IMMUNOLOGY, 2000, 199 (01) :37-42

[70]

KOJIMA A, 1980, LAB INVEST, V42, P387

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