Berberine inhibits adipogenesis in high-fat diet-induced obesity mice

被引：99

作者：

Hu, Yueshan ^{[1
]}

Davies, Gareth E. ^{[1
,2
,3
]}

机构：

[1] S Dakota State Univ, Dept Pharmaceut Sci, Coll Pharm, Brookings, SD 57007 USA

[2] Avera Behav Hlth Ctr, Avera Inst Human Behav Genet, Sioux Falls, SD 57108 USA

[3] Univ S Dakota, Sanford Sch Med, Dept Psychiat, Sioux Falls, SD 57108 USA

来源：

FITOTERAPIA | 2010年 / 81卷 / 05期

关键词：

Berberine; Adipogenesis; Fat diet mice; PPAR gamma; C/EBP alpha; GATA; ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; 3T3-L1; ADIPOCYTES; TRANSCRIPTION FACTORS; DIFFERENTIATION; MECHANISM; GAMMA; METABOLISM; IMPACT; EVODIAMINE;

D O I：

10.1016/j.fitote.2009.10.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Our previous studies illustrated that berberine inhibited adipogenesis in murine-derived 3T3-L1 preadipocytes and human white preadipocytes. In this study, the effects of berberine on the adipogenesis of high-fat diet-induced obesity (FD) or normal diet (ND) mice and possible transcriptional impact are investigated. The results demonstrated that in FD mice, berberine reduced mouse weight gain and food intake and serum glucose, triglyceride, and total cholesterol levels accompanied with a down-regulation of PPAR gamma expression and an up-regulation of GATA-3 expression. Berberine had no adverse effects on ND mice. These encouraging findings suggest that berberine has excellent pharmacological potential to prevent obesity. Published by Elsevier B.V.

引用

页码：358 / 366

页数：9

共 35 条

[1]

Cho EJ, 2008, J MICROBIOL BIOTECHN, V18, P80

[2] Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte [J].

Choi, Bong-Hyuk ;

Ahn, In-Sook ;

Kim, Yu-Hee ;

Park, Ji-Won ;

Lee, So-Young ;

Hyun, Chang-Kee ;

Do, Myoung-Sool .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2006, 38 (06) :599-605

[3] A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model [J].

Choi, Hyounjeong ;

Eo, Haekwan ;

Park, Kyoungcheol ;

Jin, Mirim ;

Park, Eun-Jin ;

Kim, Seon-Hee ;

Park, Jeong Euy ;

Kim, Sunyoung .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 359 (03) :419-425

[4] Relationship between replication and differentiation in cultured human adipocyte precursor cells [J].

Entenmann, G ;

Hauner, H .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996, 270 (04) :C1011-C1016

[5] Transcriptional control of adipocyte formation [J].

Farmer, Stephen R. .

CELL METABOLISM, 2006, 4 (04) :263-273

[6] AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model [J].

Giri, Shailendra ;

Rattan, Ramandeep ;

Haq, Ehtishamul ;

Khan, Mushfiquddin ;

Yasmin, Rifat ;

Won, Je-song ;

Key, Lyndon ;

Singh, Avtar K. ;

Singh, Inderjit .

NUTRITION & METABOLISM, 2006, 3 (1)

[7] Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation [J].

Hu, Y. ;

Davies, G. E. .

PHYTOMEDICINE, 2009, 16 (09) :864-873

[8] Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation [J].

Hu, Yueshan ;

Fahmy, Hesham ;

Zjawiony, Jordan K. ;

Davies, Gareth E. .

FITOTERAPIA, 2010, 81 (04) :259-268

[9] Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARγ pathway [J].

Huang, Cheng ;

Zhang, Yuebo ;

Gong, Zhenwei ;

Sheng, Xiaoyan ;

Li, Zongmeng ;

Zhang, Wei ;

Qin, Ying .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 348 (02) :571-578

[10] Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet [J].

Kim, Keun-Young ;

Lee, Hye Nam ;

Kim, Yun Jung ;

Park, Taesun .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2008, 72 (07) :1772-1780

← 1 2 3 4 →