The TREK K2P channels and their role in general anaesthesia and neuroprotection

被引:178
作者
Franks, NP
Honoré, E
机构
[1] Univ London Imperial Coll Sci Technol & Med, Blackett Lab, Biophys Sect, London SW7 2AZ, England
[2] CNRS, Inst Pharmacol Mol & Cellulaire, F-06560 Valbonne, France
基金
英国医学研究理事会;
关键词
D O I
10.1016/j.tips.2004.09.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Two-pore-domain K+ (K-2P) channels are a diverse and highly regulated superfamily of channels that are thought to provide baseline regulation of membrane excitability. Of these, the TREK channels are expressed highly in the human CNS, and can be activated by temperature, membrane stretch and internal acidosis. In addition, TREK channels are sensitively activated by certain polyunsaturated fatty acids that have been shown to have neuroprotective activity and by volatile and gaseous general anaesthetics. New data derived from studies of knockout animals suggest that TREK-1 might have an important role in the general anaesthetic properties of volatile agents, such as halothane, and provide an explanation for the neuroprotective properties of polyunsaturated fatty acids.
引用
收藏
页码:601 / 608
页数:8
相关论文
共 65 条
[1]   The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid [J].
Belelli, D ;
Lambert, JJ ;
Peters, JA ;
Wafford, K ;
Whiting, PJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :11031-11036
[2]   General anaesthetic action at transmitter-gated inhibitory amino acid receptors [J].
Belelli, D ;
Pistis, M ;
Peters, JA ;
Lambert, JJ .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (12) :496-502
[3]   Polyunsaturated fatty acids induce ischemic and epileptic tolerance [J].
Blondeau, N ;
Widmann, C ;
Lazdunski, M ;
Heurteaux, C .
NEUROSCIENCE, 2002, 109 (02) :231-241
[4]   A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures [J].
Blondeau, N ;
Lauritzen, I ;
Widmann, C ;
Lazdunski, M ;
Heurteaux, C .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2002, 22 (07) :821-834
[5]   KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel [J].
Bockenhauer, D ;
Zilberberg, N ;
Goldstein, SAN .
NATURE NEUROSCIENCE, 2001, 4 (05) :486-491
[6]   Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels [J].
Chemin, J ;
Girard, C ;
Duprat, F ;
Lesage, F ;
Romey, G ;
Lazdunski, M .
EMBO JOURNAL, 2003, 22 (20) :5403-5411
[7]   Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunits [J].
Czirják, G ;
Enyedi, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (07) :5426-5432
[8]   The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].
Doyle, DA ;
Cabral, JM ;
Pfuetzner, RA ;
Kuo, AL ;
Gulbis, JM ;
Cohen, SL ;
Chait, BT ;
MacKinnon, R .
SCIENCE, 1998, 280 (5360) :69-77
[9]  
Duprat F, 2000, MOL PHARMACOL, V57, P906
[10]   An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1 [J].
Enyeart, JJ ;
Xu, L ;
Danthi, S ;
Enyeart, JA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (51) :49186-49199