Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress: A randomized controlled trial

被引:118
作者
Aghdassi, E
Wendland, BE
Steinhart, AH
Wolman, SL
Jeejeebhoy, K
Allard, JP
机构
[1] Univ Toronto, Toronto Gen Hosp, Hlth Network,Dept Med, Div Gastroenterol, Toronto, ON M5G 2C4, Canada
[2] Univ Toronto, Mt Sinai Hosp, Div Gastroenterol, Toronto, ON M5G 1X5, Canada
[3] Univ Toronto, St Michaels Hosp, Div Gastroenterol, Toronto, ON M5B 1W8, Canada
关键词
D O I
10.1016/S0002-9270(02)05894-X
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
OBJECTIVE: We showed previously that patients with Crohn's disease (CD) had increased oxidative stress and lower antioxidant vitamins compared with healthy controls. This is despite inactive or mildly active disease and maintenance therapy. The aim of this study was to evaluate in these patients the effects of antioxidant vitamin supplementation on oxidative stress. METHODS: This is a randomized controlled trial where stable but oxidatively stressed CD subjects (n = 57) were supplemented with vitamins E (800 IU) and C (1000 mg) or their placebo for 4 wk. Oxidative stress measured by breath pentane and ethane output, plasma lipid peroxides, and F2-isoprostane was assessed at baseline and at 4 wk. Disease activity was also monitored by measuring CD activity index and plasma orosomucoid. RESULTS: During supplementation, plasma vitamin C and alpha-tocopherol increased and all indices of oxidative stress decreased significantly. Disease activity remained stable. CONCLUSIONS: In this population, vitamin E and C supplementation resulted in a significant reduction in oxidative stress. This suggests that patients with inactive or mildly active CD can be oxidatively stressed and have increased requirement in antioxidant vitamins. (Am J Gastroenterol 2003;98:348-353. (C) 2003 by Am. Coll. of Gastroenterology).
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页码:348 / 353
页数:6
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