Renin-angiotensin-system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation

被引：48

作者：

Wang, Di ^{[1
]}

Chai, Xiao-qing ^{[1
]}

Magnnusen, Costan G. ^{[2
,3
]}

Zosky, Graeme R. ^{[2
,4
]}

Shu, Shu-hua ^{[1
]}

Wei, Xin ^{[1
]}

Hu, Shan-shan ^{[5
]}

机构：

[1] USTC, Div Life Sci & Med, Affiliated Hosp 1, Dept Anesthesiol & Pain Med,Anhui Prov Hosp, Hefei 230001, Anhui, Peoples R China

[2] Univ Tasmania, Coll Hlth & Med, Menzies Inst Med Res, Hobart, Tas 7001, Australia

[3] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Res, FIN-20520 Turku, Finland

[4] Univ Tasmania, Coll Hlth & Med, Sch Med, Hobart, Tas 7001, Australia

[5] Anhui Med Univ, Inst Clin Pharmacol, Hefei 230032, Anhui, Peoples R China

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2019年 / 58卷

基金：

中国国家自然科学基金;

关键词：

Renin-angiotensin system (RAS); Acute respiratory distress syndrome (ARDS); Mechanical ventilation; Ventilator-induced lung injury (VILI); INDUCED LUNG INJURY; CONVERTING ENZYME 2; II TYPE-2 RECEPTOR; RISK-FACTOR; PULMONARY-HYPERTENSION; EPITHELIAL-CELLS; APOPTOSIS; LOSARTAN; POLYMORPHISM; EXPRESSION;

D O I：

10.1016/j.pupt.2019.101833

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

While effective treatments for acute respiratory distress syndrome (ARDS) are lacking, mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with respiratory failure due to ARDS. However, as a result of the phenomenon of ventilator-induced lung injury (VILI), there is an increasing need to seek beneficial pharmacological therapies for ARDS. Recent studies have suggested the renin-angiotensin system (RAS), which consists of the ACE/Ang-II/AT1R axis and ACE2/Ang-(1-7)/MasR axis, plays a dual role in the pathogenesis of ARDS and VILI. This review highlights the deleterious action of ACE/Ang-II/AT1R axis and the beneficial role of ACE2/Ang-(1-7)/MasR axis, as well as AT2R, in VILI and ARDS, and also discusses the possibility of targeting RAS components with pharmacological interventions to improve outcomes in ARDS.

引用

页数：6

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