N-silyl-tethered radical cyclizations:: A new synthesis of γ-amino alcohols

被引：17

作者：

Blaszykowski, C ^{[1
]}

Dhimane, AL ^{[1
]}

Fensterbank, L ^{[1
]}

Malacria, M ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, UMR 7611, Chim Organ Lab, F-75252 Paris 05, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 08期

关键词：

D O I：

10.1021/ol034288j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various allylic and propargylic amines bearing a protecting group (PG) have been employed in N-silyl-tethered radical cyclizations. The resulting silapyrrolidine adducts could be smoothly oxidized, creating access to gamma-amino alcohols. The silylation, radical cyclization, and oxidation reactions could be consolidated in a one-pot process.

引用

页码：1341 / 1344

页数：4

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