Application of d6 transition metal complexes in fluorescence cell imaging

被引:655
作者
Fernandez-Moreira, Vanesa [1 ]
Thorp-Greenwood, Flora L. [1 ]
Coogan, Michael P. [1 ]
机构
[1] Cardiff Univ, Dept Chem, Cardiff CF10 3AT, Cymru Wales, Wales
关键词
AMIDODIPYRIDOQUINOXALINE BIOTIN COMPLEXES; RESONANCE ENERGY-TRANSFER; EXCITED-STATE PROPERTIES; INDOLE-BINDING PROTEINS; IN-VITRO; POLYPYRIDINE COMPLEXES; CROSS-LINKING; ELECTROCHEMICAL PROPERTIES; PHOTOPHYSICAL PROPERTIES; IRIDIUM(III) COMPLEXES;
D O I
10.1039/b917757d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Luminescent d(6) transition metal complexes have often been proposed as useful fluorophores for cell imaging due to their attractive photophysical attributes, but until very recently their actual applications have been scarce, and largely limited to ruthenium complexes in DNA and oxygen sensing. In the last few years, however, there has been an increasing number of reports of the design and application in cellular studies of a diverse range of Ir, Re and Ru complexes tailor-made for imaging applications. The design principles, uptake and cellular localisation of this new class of imaging agents are presented in context in this feature article.
引用
收藏
页码:186 / 202
页数:17
相关论文
共 126 条
[1]   3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium:: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria [J].
Amoroso, Angelo J. ;
Arthur, Richard J. ;
Coogan, Michael P. ;
Court, Jonathan B. ;
Fernandez-Moreira, Vanesa ;
Hayes, Anthony J. ;
Lloyd, David ;
Millet, Coralie ;
Pope, Simon J. A. .
NEW JOURNAL OF CHEMISTRY, 2008, 32 (07) :1097-1102
[2]   Rhenium fac tricarbonyl bisimine complexes:: biologically useful fluorochromes for cell imaging applications [J].
Amoroso, Angelo J. ;
Coogan, Michael P. ;
Dunne, Jennifer E. ;
Fernandez-Moreira, Vanesa ;
Hess, Jacob B. ;
Hayes, Anthony J. ;
Lloyd, David ;
Millet, Coralie ;
Pope, Simon J. A. ;
Williams, Craig .
CHEMICAL COMMUNICATIONS, 2007, (29) :3066-3068
[3]  
[Anonymous], 2002, SMALL MOL DNA RNA BI
[4]   Ferrocenoyl pyridine arene ruthenium complexes with anticancer properties:: Synthesis, structure, electrochemistry, and cytotoxicity [J].
Auzias, Mathieu ;
Therrien, Bruno ;
Suess-Fink, Georg ;
Stepnicka, Petr ;
Ang, Wee Han ;
Dyson, Paul J. .
INORGANIC CHEMISTRY, 2008, 47 (02) :578-583
[5]   COMPARISON OF 3 COMMON AMINE REACTIVE FLUORESCENT-PROBES USED FOR CONJUGATION TO BIOMOLECULES BY CAPILLARY ZONE ELECTROPHORESIS [J].
BANKS, PR ;
PAQUETTE, DM .
BIOCONJUGATE CHEMISTRY, 1995, 6 (04) :447-458
[6]   Selective cell uptake of modified Tat peptide-fluorophore conjugates in rat retina ex vivo and in vivo models [J].
Barnett, EM ;
Elangovan, B ;
Bullok, KE ;
Piwnica-Worms, D .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (06) :2589-2595
[7]   Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals [J].
Bartholomae, Mark ;
Valliant, John ;
Maresca, Kevin P. ;
Babich, John ;
Zubieta, Jon .
CHEMICAL COMMUNICATIONS, 2009, (05) :493-512
[8]   TRIS(PHENANTHROLINE)RUTHENIUM(II) - STEREOSELECTIVITY IN BINDING TO DNA [J].
BARTON, JK ;
DANISHEFSKY, AT ;
GOLDBERG, JM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (07) :2172-2176
[9]   Transition metal and organometallic anion complexation agents [J].
Beer, PD ;
Hayes, EJ .
COORDINATION CHEMISTRY REVIEWS, 2003, 240 (1-2) :167-189
[10]   Design, Synthesis, and Imaging of Small Amphiphilic Rhenium and 99mTechnetium Tricarbonyl Complexes [J].
Boros, Eszter ;
Hafeli, Urs O. ;
Patrick, Brian O. ;
Adam, Michael J. ;
Orvig, Chris .
BIOCONJUGATE CHEMISTRY, 2009, 20 (05) :1002-1009