Cytokines, virokines and the evolution of immunity

被引:10
作者
Dower, SK [1 ]
机构
[1] Univ Sheffield, Royal Hallamshire Hosp, Div Genom Med, Sheffield S10 2JF, S Yorkshire, England
关键词
D O I
10.1038/80799
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In a new twist, the cytokine IL-10, if present when leukocytes are activated, can disconnect chemokine receptors from signaling for cell migration. The receptors act as a “sink” for soaking up chemokines, thus providing the perfect decoy.
引用
收藏
页码:367 / 368
页数:2
相关论文
共 10 条
[1]   A SOLUBLE RECEPTOR FOR INTERLEUKIN-1-BETA ENCODED BY VACCINIA VIRUS - A NOVEL MECHANISM OF VIRUS MODULATION OF THE HOST RESPONSE TO INFECTION [J].
ALCAMI, A ;
SMITH, GL .
CELL, 1992, 71 (01) :153-167
[2]   A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling [J].
Bowie, A ;
Kiss-Toth, E ;
Symons, JA ;
Smith, GL ;
Dower, SK ;
O'Neill, LAJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10162-10167
[3]   INTERLEUKIN-1 TYPE-II RECEPTOR - A DECOY TARGET FOR IL-1 THAT IS REGULATED BY IL-4 [J].
COLOTTA, F ;
RE, F ;
MUZIO, M ;
BERTINI, R ;
POLENTARUTTI, N ;
SIRONI, M ;
GIRI, JG ;
DOWER, SK ;
SIMS, JE ;
MANTOVANI, A .
SCIENCE, 1993, 261 (5120) :472-475
[4]   Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys [J].
D'Amico, G ;
Frascaroli, G ;
Bianchi, G ;
Transidico, P ;
Doni, A ;
Vecchi, A ;
Sozzani, S ;
Allavena, P ;
Mantovani, A .
NATURE IMMUNOLOGY, 2000, 1 (05) :387-391
[5]   Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog [J].
Damon, I ;
Murphy, PM ;
Moss, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6403-6407
[6]   The cowpox virus-encoded homolog of the vaccinia virus complement control protein is an inflammation modulatory protein [J].
Miller, CG ;
Shchelkunov, SN ;
Kotwal, GJ .
VIROLOGY, 1997, 229 (01) :126-133
[7]   Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI [J].
Moore, Kevin W. ;
Vieira, Paulo ;
Fiorentino, David F. ;
Trounstine, Mary L. ;
Khan, Tariq A. ;
Mosmann, Timothy R. .
JOURNAL OF IMMUNOLOGY, 2012, 189 (05) :1230-1234
[8]   MOLECULAR MIMICRY AND THE GENERATION OF HOST DEFENSE PROTEIN DIVERSITY [J].
MURPHY, PM .
CELL, 1993, 72 (06) :823-826
[9]   VACCINIA AND COWPOX VIRUSES ENCODE A NOVEL SECRETED INTERLEUKIN-1-BINDING PROTEIN [J].
SPRIGGS, MK ;
HRUBY, DE ;
MALISZEWSKI, CR ;
PICKUP, DJ ;
SIMS, JE ;
BULLER, RML ;
VANSLYKE, J .
CELL, 1992, 71 (01) :145-152
[10]   PURIFICATION AND CHARACTERIZATION OF A NOVEL SOLUBLE RECEPTOR FOR INTERLEUKIN-1 [J].
SYMONS, JA ;
EASTGATE, JA ;
DUFF, GW .
JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (05) :1251-1254