Total synthesis of(-)-pateamine, a novel polyene bis-macrolide with immunosuppressive activity from the sponge Mycale sp.

被引：29

作者：

Remuiñán, MJ ^{[1
]}

Pattenden, G ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)01241-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and convergent synthesis of the polyene thiazole-containing 19-membered bis-lactone (-)-pateamine 1 is described. The synthesis features both the intra- and intermolecular Stille sp(2)-sp(2) coupling reactions to elaborate the E,Z-diene macrolide core and the side-chain all-E polyene portion of the natural product, and highlights the scope for enantiopure sulfinimine intermediates in the synthesis of chiral beta-amino ester moieties in complex structures. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7367 / 7371

页数：5

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