Solid-phase synthesis of a double 4-pyridinyl terminated Leu-Ala-Leu tripeptide and macrocyclization by Palladium(II) coordination

被引：10

作者：

Albrecht, M

Stortz, P

Engeser, M

Schalley, CA

机构：

[1] Rhein Westfal TH Aachen, Inst Chim Organ, D-52074 Aachen, Germany

[2] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

来源：

SYNLETT | 2004年 / 15期

关键词：

solid-phase; coupling; pyridines; peptides; macrocycles;

D O I：

10.1055/s-2004-835624

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Leu-Ala-Leu tripeptide, which bears pyridinyl units at the N- as well as C-terminus, is prepared by combination of solid- and solution-phase synthesis. With the Pd(en)(2+) fragment it forms a mixture of 1:1 and 2:2 complexes, with the mononuclear complex probably being the dominating species.

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收藏

页码：2821 / 2823

页数：3

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