DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications

被引：68

作者：

Campolongo, Michael J. ^{[2
]}

Tan, Shawn J. ^{[2
]}

Xu, Jianfeng ^{[3
]}

Luo, Dan ^{[1
]}

机构：

[1] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Biomed Engn, Ithaca, NY 14853 USA

[3] Arkansas State Univ, Arkansas Biosci Inst, State Univ, AR 72467 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 06期

关键词：

DNA; Nanomedicine; Polymer topologies; Nano-assembly; DNA nanostructures; SINGLE-NUCLEOTIDE POLYMORPHISM; BIO-BARCODE ASSAY; EXPONENTIAL ENRICHMENT; COLORIMETRIC DETECTION; MULTIPLEXED DETECTION; SYSTEMATIC EVOLUTION; NANOPARTICLE PROBES; EMERGING CLASS; BASIC RESEARCH; DRUG-DELIVERY;

D O I：

10.1016/j.addr.2010.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanomedicine, the application of nanotechnology to medicine, encompasses a broad spectrum of fields including molecular detection, diagnostics, drug delivery, gene regulation and protein production. In recent decades, DNA has received considerable attention for its functionality and versatility, allowing it to help bridge the gap between materials science and biological systems. The use of DNA as a structural nanoscale material has opened a new avenue towards the rational design of DNA nanostructures with different polymeric topologies. These topologies, in turn, possess unique characteristics that translate to specific therapeutic and diagnostic strategies within nanomedicine. (C) 2010 Elsevier By. All rights reserved.

引用

页码：606 / 616

页数：11

共 157 条

[51] Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds [J].

Huang, YC ;

Riddle, K ;

Rice, KG ;

Mooney, DJ .

HUMAN GENE THERAPY, 2005, 16 (05) :609-617

[52] Novel complexation hydrogels for oral peptide delivery:: In vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers [J].

Ichikawa, H ;

Peppas, NA .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 67A (02) :609-617

[53] Discovery and development of anticancer aptamers [J].

Ireson, Christopher R. ;

Kelland, Lloyd R. .

MOLECULAR CANCER THERAPEUTICS, 2006, 5 (12) :2957-2962

[54] Utilization of DNA as functional materials: Preparation of filters containing DNA insolubilized with alginic acid gel [J].

Iwata, K ;

Sawadaishi, T ;

Nishimura, S ;

Tokura, S ;

Nishi, N .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1996, 18 (1-2) :149-150

[55]

Jayasena SD, 1999, CLIN CHEM, V45, P1628

[56] Survival of lactic acid bacteria in simulated gastrointestinal juice protected by a DNA-based complex gel [J].

Jonganurakkun, B ;

Liu, XD ;

Nodasaka, Y ;

Nomizu, M ;

Nishi, N .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2003, 14 (11) :1269-1281

[57] AN IMMOBILE NUCLEIC-ACID JUNCTION CONSTRUCTED FROM OLIGONUCLEOTIDES [J].

KALLENBACH, NR ;

MA, RI ;

SEEMAN, NC .

NATURE, 1983, 305 (5937) :829-831

[58] Bioresponsive hydrogel microlenses [J].

Kim, J ;

Nayak, S ;

Lyon, LA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (26) :9588-9592

[59] DNA-alginate complex recognized by autoantibodies against DNA [J].

Kitamura, H ;

Matsuura, E ;

Nagata, A ;

Sakairi, N ;

Tokura, S ;

Nishi, N .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1997, 20 (01) :75-77

[60] Hydrogel biomaterials: A smart future? [J].

Kopecek, Jindrich .

BIOMATERIALS, 2007, 28 (34) :5185-5192

← 1 2 3 4 5 6 7 8 9 10 →