miRNAs as molecular biomarkers of cancer

被引：72

作者：

Fabbri, Muller ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2010年 / 10卷 / 04期

关键词：

biomarkers; cancer; miRNAs; oncogene; tumor-suppressor gene; CHRONIC LYMPHOCYTIC-LEUKEMIA; ESTROGEN-RECEPTOR-ALPHA; ACUTE MYELOID-LEUKEMIA; HUMAN BREAST-CANCER; MICRORNA EXPRESSION PATTERNS; CELL-PROLIFERATION; DOWN-REGULATION; LUNG-CANCER; DERIVATIVE CHROMOSOME-9; PROGNOSTIC IMPLICATIONS;

D O I：

10.1586/ERM.10.27

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

miRNAs are noncoding RNAs that regulate gene expression. The advent of high-throughput techniques has revealed that miRNA expression is deregulated in almost all human tumors (both solid and hematologic) with respect to the normal tissue counterpart. These differences frequently recur in tumor-specific miRNA signatures, which are very helpful to diagnose the tissue of origin of the neoplasia, and sometimes also specific tumor subtypes. Increasing evidence also supports a role for miRNAs as prognostic biomarkers of human cancers. Finally, miRNAs are differentially expressed in the blood of cancer patients versus healthy donors, providing a rationale for the detection of miRNAs and diagnostic and prognostic circulating biomarkers.

引用

收藏

页码：435 / 444

页数：10

相关论文

共 125 条

[1] The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-α (ERα) and represses ERα messenger RNA and protein expression in breast cancer cell lines [J].

Adams, Brian D. ;

Furneaux, Henry ;

White, Bruce A. .

MOLECULAR ENDOCRINOLOGY, 2007, 21 (05) :1132-1147

[2] Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia [J].

Agirre, Xabier ;

Vilas-Zornoza, Amaia ;

Jimenez-Velasco, Antonio ;

Ignacio Martin-Subero, Jose ;

Cordeu, Lucia ;

Garate, Leire ;

San Jose-Eneriz, Edurne ;

Abizanda, Gloria ;

Rodriguez-Otero, Paula ;

Fortes, Puri ;

Rifon, Jose ;

Bandres, Eva ;

Jose Calasanz, Maria ;

Martin, Vanesa ;

Heiniger, Anabel ;

Torres, Antonio ;

Siebert, Reiner ;

Roman-Gomez, Jose ;

Prosper, Felipe .

CANCER RESEARCH, 2009, 69 (10) :4443-4453

[3] Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth [J].

Agirre, Xabier ;

Jimenez-Velasco, Antonio ;

San Jose-Eneriz, Edurne ;

Garate, Leire ;

Bandres, Eva ;

Cordeu, Lucia ;

Aparicio, Oscar ;

Saez, Borja ;

Navarro, German ;

Vilas-Zornoza, Amaia ;

Perez-Roger, Ignacio ;

Garcia-Foncillas, Jesus ;

Torres, Antonio ;

Heiniger, Anabel ;

Jose Calasanz, Maria ;

Fortes, Puri ;

Roman-Gomez, Jose ;

Prosper, Felipe .

MOLECULAR CANCER RESEARCH, 2008, 6 (12) :1830-1840

[4]

AKAO Y, 2007, CANC SCI

[5] MicroRNA-143 and-145 in colon cancer [J].

Akao, Yukihiro ;

Nakagawa, Yoshihito ;

Naoe, Tomoki .

DNA AND CELL BIOLOGY, 2007, 26 (05) :311-320

[6]

Ambros Victor, 2004, Methods Mol Biol, V265, P131

[7] AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer [J].

Anzick, SL ;

Kononen, J ;

Walker, RL ;

Azorsa, DO ;

Tanner, MM ;

Guan, XY ;

Sauter, G ;

Kallioniemi, OP ;

Trent, JM ;

Meltzer, PS .

SCIENCE, 1997, 277 (5328) :965-968

[8] Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues [J].

Bandres, E. ;

Cubedo, E. ;

Agirre, X. ;

Malumbres, R. ;

Zarate, R. ;

Ramirez, N. ;

Abajo, A. ;

Navarro, A. ;

Moreno, I. ;

Monzo, M. ;

Garcia-Foncillas, J. .

MOLECULAR CANCER, 2006, 5 (1)

[9] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[10] MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype [J].

Blenkiron, Cherie ;

Goldstein, Leonard D. ;

Thorne, Natalie P. ;

Spiteri, Inmaculada ;

Chin, Suet-Feung ;

Dunning, Mark J. ;

Barbosa-Morais, Nuno L. ;

Teschendorff, Andrew E. ;

Green, Andrew R. ;

Ellis, Ian O. ;

Tavare, Simon ;

Caldas, Carlos ;

Miska, Eric A. .

GENOME BIOLOGY, 2007, 8 (10)

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