Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

被引：583

作者：

Masliah, E ^{[1
]}

Mallory, M

Alford, M

DeTeresa, R

Hansen, LA

McKeel, DW

Morris, JC

机构：

[1] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Pathol, La Jolla, CA 92093 USA

[3] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

来源：

NEUROLOGY | 2001年 / 56卷 / 01期

关键词：

D O I：

10.1212/WNL.56.1.127

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to I) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.

引用

页码：127 / 129

页数：3

共 10 条

[1] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].

ARRIAGADA, PV ;

GROWDON, JH ;

HEDLEYWHYTE, ET ;

HYMAN, BT .

NEUROLOGY, 1992, 42 (03) :631-639

[2] NEUROPATHOLOGICAL STAGING OF ALZHEIMER LESIONS AND INTELLECTUAL STATUS IN ALZHEIMERS AND PARKINSONS-DISEASE PATIENTS [J].

BANCHER, C ;

BRAAK, H ;

FISCHER, P ;

JELLINGER, KA .

NEUROSCIENCE LETTERS, 1993, 162 (1-2) :179-182

[3] IMAGE-ANALYSIS OF BETA-AMYLOID LOAD IN ALZHEIMERS-DISEASE AND RELATION TO DEMENTIA SEVERITY [J].

CUMMINGS, BJ ;

COTMAN, CW .

LANCET, 1995, 346 (8989) :1524-1528

[4] Synaptotagmin, a synaptic vesicle protein, is present in human cerebrospinal fluid - A new biochemical marker for synaptic pathology in Alzheimer disease? [J].

Davidsson, P ;

Jahn, R ;

Bergquist, J ;

Ekman, R ;

Blennow, K .

MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1996, 27 (02) :195-210

[5] The synaptic protein NACP is abnormally expressed during the progression of Alzheimer's disease [J].

Iwai, A ;

Masliah, E ;

Sundsmo, MP ;

DeTeresa, R ;

Mallory, M ;

Salmon, DP ;

Saitoh, T .

BRAIN RESEARCH, 1996, 720 (1-2) :230-234

[6] Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease [J].

Lue, LF ;

Kuo, YM ;

Roher, AE ;

Brachova, L ;

Shen, Y ;

Sue, L ;

Beach, T ;

Kurth, JH ;

Rydel, RE ;

Rogers, J .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (03) :853-862

[7] SYNAPTIC AND NEURITIC ALTERATIONS DURING THE PROGRESSION OF ALZHEIMERS-DISEASE [J].

MASLIAH, E ;

MALLORY, M ;

HANSEN, L ;

DETERESA, R ;

ALFORD, M ;

TERRY, R .

NEUROSCIENCE LETTERS, 1994, 174 (01) :67-72

[8] Clinical Dementia Rating training and reliability in multicenter studies: The Alzheimer's Disease Cooperative Study experience [J].

Morris, JC ;

Ernesto, C ;

Schafer, K ;

Coats, M ;

Leon, S ;

Sano, M ;

Thal, LJ .

NEUROLOGY, 1997, 48 (06) :1508-1510

[9]

MUNDIGL O, 1995, EUR J CELL BIOL, V66, P246

[10] PHYSICAL BASIS OF COGNITIVE ALTERATIONS IN ALZHEIMERS-DISEASE - SYNAPSE LOSS IS THE MAJOR CORRELATE OF COGNITIVE IMPAIRMENT [J].

TERRY, RD ;

MASLIAH, E ;

SALMON, DP ;

BUTTERS, N ;

DETERESA, R ;

HILL, R ;

HANSEN, LA ;

KATZMAN, R .

ANNALS OF NEUROLOGY, 1991, 30 (04) :572-580

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