NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia

被引：53

作者：

Falini, Brunangelo ^{[1
]}

Mecucci, Cristina ^{[1
]}

Saglio, Giuseppe ^{[2
]}

Lo Coco, Francesco ^{[3
]}

Diverio, Daniela ^{[4
]}

Brown, Patrick ^{[5
]}

Pane, Fabrizio ^{[6
]}

Mancini, Marco ^{[4
]}

Martelli, Maria Paola ^{[1
]}

Pileri, Stefano ^{[7
]}

Haferlach, Torsten ^{[8
]}

Haferlach, Claudia ^{[8
]}

Schnittger, Susanne ^{[8
]}

机构：

[1] Univ Perugia, Inst Hematol, Perugia, Italy

[2] Univ Turin, San Luigi Hosp, Dept Clin & Biol Sci, Turin, Italy

[3] Policlin Tor Vergata, Dept Biopathol & Diagnost Imaging, Rome, Italy

[4] Policlin La Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy

[5] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA

[6] Univ Federico II, Dept Biochem & Med Biotechnol, Neples, Italy

[7] Univ Bologna, Policlin S Orsola, Lab Hematopathol, Bologna, Italy

[8] Munich Leukemia Lab GmbH, Munich, Germany

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 03期

关键词：

acute myeloid leukemia; nucleophosmin; NPM; mutations; antibodies; immunohistochemistry;

D O I：

10.3324/haematol.12153

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc(+) acute myeloid leukemia) represents one-third of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification.

引用

页码：439 / 442

页数：4

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