One-Pot Synthesis of Pyrimido[1,6-a]indol-1(2H)-one Derivatives by a Nucleophilic Addition/Cu-Catalyzed N-Arylation/Pd-Catalyzed C-H Activation Sequential Process

被引：70

作者：

Wang, Zhi-Jing ^{[1
]}

Yang, Jian-Guo ^{[2
]}

Yang, Fan ^{[1
]}

Bao, Weiliang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Zhejiang, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 317000, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 13期

基金：

高等学校博士学科点专项科研基金;

关键词：

EFFICIENT DOMINO SYNTHESIS; BOND FORMATION; CYCLIZATION CASCADE; COUPLING REACTIONS; MODULAR SYNTHESIS; COPPER; ARYL; INDOLES; FUNCTIONALIZATION; HETEROCYCLES;

D O I：

10.1021/ol101041e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and convenient one-pot synthesis of pyrimido[1,6-a]indol-1(2H)-one derivatives through a nucleophilic addition/Cu-catalyzed N-arylation/Pd-catalyzed C H activation sequential process is described. The reaction of easily prepared ortho-gem-dibromovinyl isocyanates with N-alkylanilines gave the desired indole derivatives in moderate to good yields.

引用

页码：3034 / 3037

页数：4

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