Gene function in mouse embryogenesis: get set for gastrulation

被引：438

作者：

Tam, Patrick P. L. ^{[1
]}

Loebel, David A. F.

机构：

[1] Univ Sydney, Embryol Unit, Childrens Med Res Inst, Westmead, NSW 2145, Australia

[2] Univ Sydney, Fac Med, Westmead, NSW 2145, Australia

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrg2084

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

During early mouse embryogenesis, temporal and spatial regulation of gene expression and cell signalling influences lineage specification, embryonic polarity, the patterning of tissue progenitors and the morphogenetic movement of cells and tissues. Uniquely in mammals, the extraembryonic tissues are the source of signals for lineage specification and tissue patterning. Here we discuss recent discoveries about the lead up to gastrulation, including early manifestations of asymmetry, coordination of cell and tissue movements and the interactions of transcription factors and signalling activity for lineage allocation and germ-layer specification.

引用

页码：368 / 381

页数：14

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