Oligonucleotides with alternating anionic and cationic phosphoramidate linkages: Synthesis and hybridization of stereo-uniform isomers

被引：24

作者：

Horn, T ^{[1
]}

Chaturvedi, S ^{[1
]}

Balasubramaniam, TN ^{[1
]}

Letsinger, RL ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,DEPT CHEM,EVANSTON,IL 60208

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 06期

关键词：

D O I：

10.1016/0040-4039(95)02309-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An oligonucleotide containing alternating anionic and stereo-uniform cationic dimethylaminopropylphosphoramidate linkages, d(T+T-)(7)T, is shown to bind with unusually high affinity to DNA [poly(dA) and d(C(2)A(15)C(2))] and RNA [poly(rA)] targets in solutions of low ionic strength. The isomeric oligomer with the opposite configuration at the phosphoramidate links binds much less efficiently.

引用

页码：743 / 746

页数：4

共 9 条

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