Practical synthesis and elaboration of methyl 7-chloroindole-4-carboxylate

被引：11

作者：

Alper, PB ^{[1
]}

Nguyen, KT ^{[1
]}

机构：

[1] Novartis Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 05期

关键词：

D O I：

10.1021/jo026434p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of a previously unknown indole derivative is presented. The route reported herein allows for the preparation of multihundred gram quantities of material without any chromatographic purification. Conditions are presented for the Pd-catalyzed elaboration of one of the "diversity generating elements" of this important pharmacophore.

引用

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页码：2051 / 2053

页数：3

相关论文

共 66 条

[21] CHEMISTRY OF SULFILIMINES [J].

GILCHRIST, TL ;

MOODY, CJ .

CHEMICAL REVIEWS, 1977, 77 (03) :409-435

[22] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS [J].

GORDON, EM ;

BARRETT, RW ;

DOWER, WJ ;

FODOR, SPA ;

GALLOP, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) :1385-1401

[23] Recent developments in indole ring synthesis-methodology and applications [J].

Gribble, GW .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (07) :1045-1075

[24]

GRIBBLE GW, 1996, COMPREHENSIVE HETERO, V2, P207, DOI DOI 10.1016/B978-008096518-5.00043-5

[25]

HUGHES DL, 1993, ORG PREP P INT, P607

[26] Application of polymer-bound phosphonium salts as traceless supports for solid phase synthesis [J].

Hughes, I .

TETRAHEDRON LETTERS, 1996, 37 (42) :7595-7598

[27] Fischer indole synthesis on a solid support [J].

Hutchins, SM ;

Chapman, KT .

TETRAHEDRON LETTERS, 1996, 37 (28) :4869-4872

[28]

JENNER P, 1983, British Journal of Pharmacology, V80, p667P

[29] DOPAMINE-RECEPTORS - FUNCTIONS, SUBTYPES AND EMERGING CONCEPTS [J].

KAISER, C ;

JAIN, T .

MEDICINAL RESEARCH REVIEWS, 1985, 5 (02) :145-229

[30]

KAZANIETZ MG, 1993, MOL PHARMACOL, V44, P298

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