Practical synthesis and elaboration of methyl 7-chloroindole-4-carboxylate

被引：11

作者：

Alper, PB ^{[1
]}

Nguyen, KT ^{[1
]}

机构：

[1] Novartis Fdn, Genom Inst, San Diego, CA 92121 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 05期

关键词：

D O I：

10.1021/jo026434p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of a previously unknown indole derivative is presented. The route reported herein allows for the preparation of multihundred gram quantities of material without any chromatographic purification. Conditions are presented for the Pd-catalyzed elaboration of one of the "diversity generating elements" of this important pharmacophore.

引用

页码：2051 / 2053

页数：3

共 66 条

[61]

2-H

[62] Heck reaction on solid support: Synthesis of indole analogs [J].