Effects of α1-acid glycoprotein in different rodent models of shock

被引:34
作者
Muchitsch, EM [1 ]
Auer, W [1 ]
Pichler, L [1 ]
机构
[1] Immuno AG Wien, Dept Pharmacol & Toxicol, A-1221 Vienna, Austria
关键词
alpha(1)-acid glycoprotein; rodents; lipopolysaccharide; septic peritonitis; hemorrhagic shock;
D O I
10.1111/j.1472-8206.1998.tb00938.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
It was the aim of the present study to investigate the effects of the acute phase protein alpha(1)-acid glycoprotein in different models of shock. The human plasma preparation used was without effect on mortality in lipopolysaccharide-injected mice when administered in two different doses (1 or 0.33 g/kg iv) and according to different treatment schedules. The same preparation significantly increased survival rate (48 h) in rats with septic peritonitis. This effect was seen when alpha(1)-acid glycoprotein (200 mg/kg iv) was given 15 min prior to and 24 h after cecal puncture. All other dose regimes tested were without significant effect on survival rate. A hemorrhagic/hypovolemic shock model (including a defined trauma) in rats resuscitated with 200 mg/kg alpha(1)-acid glycoprotein resulted in significantly higher values of mean arterial blood pressure, cardiac output and stroke volume when compared to corresponding values obtained after resuscitation with Ringer's solution or 200 mg/kg albumin iv (free of alpha(1)-acid glycoprotein; placebo formulation). Taking all other possible mechanisms of alpha(1)-acid glycoprotein into consideration, the partially protective effects of the preparation are explained by enhancing the capillary barrier function and thereby maintaining perfusion of vital organs. (C) 1998 Elsevier, Paris.
引用
收藏
页码:173 / 181
页数:9
相关论文
共 15 条
[1]   IMMUNOSUPPRESSION BY HUMAN-PLASMA ALPHA-1-ACID GLYCOPROTEIN - IMPORTANCE OF THE CARBOHYDRATE MOIETY [J].
BENNETT, M ;
SCHMID, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (10) :6109-6113
[2]   ALPHA-1-ACID GLYCOPROTEIN POTENTIATES LIPOPOLYSACCHARIDE-INDUCED SECRETION OF INTERLEUKIN-1-BETA, INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA BY HUMAN MONOCYTES AND ALVEOLAR AND PERITONEAL-MACROPHAGES [J].
BOUTTEN, A ;
DEHOUX, M ;
DESCHENES, M ;
ROUZEAU, JD ;
BORIES, PN ;
DURAND, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (10) :2687-2695
[3]  
CHAUDRY IH, 1979, SURGERY, V85, P205
[4]  
COSTELLO MJ, 1984, CLIN EXP IMMUNOL, V55, P465
[5]   MODULATION OF MICROVESSEL WALL CHARGE BY PLASMA GLYCOPROTEIN OROSOMUCOID [J].
CURRY, FE ;
RUTLEDGE, JC ;
LENZ, JF .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (05) :H1354-H1359
[6]   OROSOMUCOID AS ONE OF THE SERUM COMPONENTS CONTRIBUTING TO NORMAL CAPILLARY PERMSELECTIVITY IN RAT SKELETAL-MUSCLE [J].
HARALDSSON, B ;
RIPPE, B .
ACTA PHYSIOLOGICA SCANDINAVICA, 1987, 129 (01) :127-135
[7]   PROTECTION BY ALPHA(1)-ACID GLYCOPROTEIN AGAINST TUMOR NECROSIS FACTOR-INDUCED LETHALITY [J].
LIBERT, C ;
BROUCKAERT, P ;
FIERS, W .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1571-1575
[8]  
McNamara P J, 1989, Prog Clin Biol Res, V300, P307
[9]  
Muchitsch EM, 1996, ARCH INT PHARMACOD T, V331, P313
[10]   ALPHA-1-ACID GLYCOPROTEIN EXPRESSION IN HUMAN-LEUKOCYTES - POSSIBLE CORRELATION BETWEEN ALPHA-1-ACID GLYCOPROTEIN AND INFLAMMATORY CYTOKINES IN RHEUMATOID-ARTHRITIS [J].
NAKAMURA, T ;
BOARD, PG ;
MATSUSHITA, K ;
TANAKA, H ;
MATSUYAMA, T ;
MATSUDA, T .
INFLAMMATION, 1993, 17 (01) :33-45