Molecular regulation of angiogenesis and lymphangiogenesis

被引：1525

作者：

Adams, Ralf H. ^{[1
]}

Alitalo, Kari

机构：

[1] Canc Res UK London Res Inst, Vasc Dev Lab, London WC2A 3PX, England

[2] Univ Helsinki, Lab Mol Canc Biol, FI-00014 Helsinki, Finland

[3] Univ Helsinki, Ludwig Inst Canc Res, Biomedicum Helsinki, FI-00014 Helsinki, Finland

[4] Univ Helsinki, Haartman Inst, FI-00014 Helsinki, Finland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 06期

基金：

美国国家卫生研究院; 芬兰科学院;

关键词：

D O I：

10.1038/nrm2183

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Blood vessels and lymphatic vessels form extensive networks that are essential for the transport of fluids, gases, macromolecules and cells within the large and complex bodies of vertebrates. Both of these vascular structures are lined with endothelial cells that integrate functionally into different organs, acquire tissue- specific specialization and retain plasticity; thereby, they permit growth during tissue repair or in disease settings. The angiogenic growth of blood vessels and lymphatic vessels coordinates several biological processes such as cell proliferation, guided migration, differentiation and cell-cell communication.

引用

页码：464 / 478

页数：15

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