Recommendation for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs)

被引:257
作者
Paterson, DL
机构
[1] Inst Trapianti Terapie Alta Specializzaz I, Infect Dis Sect, I-90134 Palermo, Italy
[2] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, PA USA
关键词
ESBL; extended-spectrum beta-lactamase; beta-lactamase; carbapenems; cephadosporins; Klebsiella;
D O I
10.1046/j.1469-0691.2000.00107.x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Extended-spectrum beta -lactamase (ESBL)-producing organisms are a global problem. No randomized controlled trials have ever been performed to guide optimal treatment. However, in vitro studies and observational studies strongly suggest that carbapenems (imipenem or meropenem) should be regarded as drugs of choice for serious infections due to ESBL-producing organisms. Other beta -lactam antibiotics (cefepime, beta -lactam/beta -lactamase inhibitor combinations) are not suitable as first-line therapy. The increasing frequency of the association between quinolone resistance and ESBL production have greatly limited the role of this class of antibiotic against ESBL producers.
引用
收藏
页码:460 / 463
页数:4
相关论文
共 26 条
[1]  
[Anonymous], M100S10 NCCLS
[2]   Antimicrobial resistance amongst Klebsiella spp. collected from intensive care units in Southern and Western Europe in 1997-1998 [J].
Babini, GS ;
Livermore, DM .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (02) :183-189
[3]   Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the loss of an outer membrane protein [J].
Bradford, PA ;
Urban, C ;
Mariano, N ;
Projan, SJ ;
Rahal, JJ ;
Bush, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :563-569
[4]  
BRUNBUISSON C, 1987, LANCET, V2, P302
[5]  
Casellas Jose-Maria, 1999, Journal of Antimicrobial Chemotherapy, V44, P16
[6]   Study of an outbreak of cefoxitin-resistant Klebsiella pneumoniae in a general hospital [J].
Gazouli, M ;
Kaufmann, ME ;
Tzelepi, E ;
Dimopoulou, H ;
Paniara, O ;
Tzouvelekis, LS .
JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (02) :508-510
[7]   Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens [J].
Jacoby, G ;
Han, P ;
Tran, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (08) :1830-1831
[8]   Treatment failure due to extended spectrum beta-lactamase [J].
Karas, JA ;
Pillay, DG ;
Muckart, D ;
Sturm, AW .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 (01) :203-204
[9]   Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp from intensive care units in Europe [J].
Livermore, DM ;
Yuan, M .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 38 (03) :409-424
[10]   Emergence of a carbapenem-resistant Klebsiella pneumoniae [J].
MacKenzie, FM ;
Forbes, KJ ;
DoraiJohn, T ;
Amyes, SGB ;
Gould, IM .
LANCET, 1997, 350 (9080) :783-783