Improved venous suppression and spatial resolution with SENSE in elliptical centric 3D contrast-enhanced MR angiography

The elliptical centric (EC) view order samples a 3DFT acquisition from the center of k-space outward, and when applied to contrast-enhanced MR angiography (CE-MRA) provides intrinsic venous suppression. This is because the veins enhance several seconds after the scan is initiated, and are thus encoded solely by noncentral k-space frequencies. A separate method, sensitivity encoding (SENSE), accelerates the k-space sampling rate by reducing the phase FOV or, equivalently, by increasing the k-space sampling interval, and has been used to increase spatiotemporal resolution. We hypothesized that by combining SENSE with EC, sampling of central k-space would be accelerated and the k-space radius at which the veins first showed contrast enhancement would be increased over a reference scan, thus providing improved venous suppression and spatial resolution without additional scan time. This hypothesis was studied with the use of phantom and carotid CE-MRA experiments, and the results demonstrated an approximate 25% reduction in venous signal when SENSE was used. (C) 2004 Wiley-Liss, Inc.