Aqua-organocatalyzed direct asymmetric aldol reaction with acyclic amino acids and organic bases with control of diastereo- and enantioselectivity

被引：65

作者：

Amedjkouh, Mohamed ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem, SE-41296 Gothenburg, Sweden

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 03期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1016/j.tetasy.2007.01.025

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An effective aqua-organocatalytic direct aldol reaction is described. Aromatic amino acids can be a bifunctional catalyst system, which demonstrate excellent reactivity, diastereoselectivity, and enantioselectivity (up to 96% ee) in water without the addition of organic solvents. Furthermore, the present study demonstrates that both diastereo and enantioselectivity can be easily modulated by the appropriate combination of an organocatalyst together with an organic base as a co-catalyst. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：390 / 395

页数：6

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