Nucleic acid vaccines: research tool or commercial reality

被引：41

作者：

Babiuk, LA ^{[1
]}

Babiuk, SL ^{[1
]}

Loehr, BI ^{[1
]}

Littel-van den Hurk, SV ^{[1
]}

机构：

[1] Univ Saskatchewan, VIDO, Saskatoon, SK S7N 5E3, Canada

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2000年 / 76卷 / 1-2期

关键词：

polynucleotide vaccines; veterinary vaccines; immunity;

D O I：

10.1016/S0165-2427(00)00198-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polynucleotide immunization has captured the imagination of numerous researchers and commercial companies around the world as a novel approach for inducing immunity in animals. Clearly, the 'proof-of-principle' has been demonstrated both in rodents and various animal species. However, to date, no commercial veterinary vaccine has been developed, or to our knowledge, is in the licensing phase. The present review summarizes the types of pathogens and host species for which polynucleotide immunization has been tried. We have tried to identify possible barriers to commercialization of this technology and areas that need attention if this promising technology is ever to become a reality in the commercial arena. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 23

页数：23

共 136 条

[31] Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells [J].

Doe, B ;

Selby, M ;

Barnett, S ;

Baenziger, J ;

Walker, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8578-8583

[32] Induction of protective immunity to Theileria annulata using two major merozite surface antigens presented by different delivery systems [J].

dOliveira, C ;

Feenstra, A ;

Vos, H ;

Osterhaus, ADME ;

Shiels, BR ;

Cornelissen, AWCA ;

Jongejan, F .

VACCINE, 1997, 15 (16) :1796-1804

[33] Sindbis virus DNA-based expression vectors: Utility for in vitro and in vivo gene transfer [J].

Dubensky, TW ;

Driver, DA ;

Polo, JM ;

Belli, BA ;

Latham, EM ;

Ibanez, CE ;

Chada, S ;

Brumm, D ;

Banks, TA ;

Mento, SJ ;

Jolly, DJ ;

Chang, SMW .

JOURNAL OF VIROLOGY, 1996, 70 (01) :508-519

[34] LIPOFECTION - A HIGHLY EFFICIENT, LIPID-MEDIATED DNA-TRANSFECTION PROCEDURE [J].

FELGNER, PL ;

GADEK, TR ;

HOLM, M ;

ROMAN, R ;

CHAN, HW ;

WENZ, M ;

NORTHROP, JP ;

RINGOLD, GM ;

DANIELSEN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7413-7417

[35]

Feltquate DM, 1997, J IMMUNOL, V158, P2278

[36] Factors influencing cellular immune responses to feline immunodeficiency virus induced by DNA vaccination [J].

Flynn, JN ;

Hosie, MJ ;

Rigby, MA ;

Mackay, N ;

Cannon, CA ;

Dunsford, T ;

Neil, JC ;

Jarrett, O .

VACCINE, 2000, 18 (11-12) :1118-1132

[37] Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes [J].

Fu, TM ;

Ulmer, JB ;

Caulfield, MJ ;

Deck, RR ;

Friedman, A ;

Wang, S ;

Liu, X ;

Donnelly, JJ ;

Liu, MA .

MOLECULAR MEDICINE, 1997, 3 (06) :362-371

[38] DNA VACCINES - PROTECTIVE IMMUNIZATIONS BY PARENTERAL, MUCOSAL, AND GENE-GUN INOCULATIONS [J].

FYNAN, EF ;

WEBSTER, RG ;

FULLER, DH ;

HAYNES, JR ;

SANTORO, JC ;

ROBINSON, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11478-11482

[39] Immunogenicity of vector DNA vaccine constructs of pseudorabies virus immediate early gene (IE180) in mice and swine [J].

Garmendia, AE ;

Chang, S ;

Tulman, ER ;

Rompato, G ;

Bu, J .

TROPICAL VETERINARY MEDICINE: MOLECULAR EPIDEMIOLOGY, HEMOPARASITES AND THEIR VECTORS, AND GENERAL TOPICS, 1998, 849 :485-489

[40] Differential cellular and humoral immune responses to HCV core and HBV envelope proteins after genetic immunizations using chimeric constructs [J].

Geissler, M ;

Tokushige, K ;

Wakita, T ;

Zurawski, VR ;

Wands, JR .

VACCINE, 1998, 16 (08) :857-867

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