Nucleic acid vaccines: research tool or commercial reality

被引：41

作者：

Babiuk, LA ^{[1
]}

Babiuk, SL ^{[1
]}

Loehr, BI ^{[1
]}

Littel-van den Hurk, SV ^{[1
]}

机构：

[1] Univ Saskatchewan, VIDO, Saskatoon, SK S7N 5E3, Canada

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2000年 / 76卷 / 1-2期

关键词：

polynucleotide vaccines; veterinary vaccines; immunity;

D O I：

10.1016/S0165-2427(00)00198-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polynucleotide immunization has captured the imagination of numerous researchers and commercial companies around the world as a novel approach for inducing immunity in animals. Clearly, the 'proof-of-principle' has been demonstrated both in rodents and various animal species. However, to date, no commercial veterinary vaccine has been developed, or to our knowledge, is in the licensing phase. The present review summarizes the types of pathogens and host species for which polynucleotide immunization has been tried. We have tried to identify possible barriers to commercialization of this technology and areas that need attention if this promising technology is ever to become a reality in the commercial arena. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 23

页数：23

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