Ph2SO/Tf2O:: a powerful promotor system in chemoselective glycosylations using thioglycosides

被引：206

作者：

Codée, JDC ^{[1
]}

Litjens, REJN ^{[1
]}

den Heeten, R ^{[1
]}

Overkleeft, HS ^{[1
]}

van Boom, JH ^{[1
]}

van der Marel, GA ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 09期

关键词：

D O I：

10.1021/ol034312t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Diphenylsulfoxide in combination with triflic anhydride provides a very potent thiophilic glycosylation promotor system, capable of activating disarmed thioglycosides. The usefulness of this novel thiophilic activator is illustrated in a successful chemoselective glycosylation sequence in which the donor thioglycoside in the first condensation step may be either armed or disarmed.

引用

页码：1519 / 1522

页数：4

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