Synthesis of variolin B

被引：21

作者：

Ahaidar, A

Fernández, D

Pérez, O

Danelón, G

Cuevas, C

Manzanares, I

Albericio, F

Joule, JA

Alvarez, M

机构：

[1] Univ Barcelona, Biomed Res Inst, E-08028 Barcelona, Spain

[2] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

[3] Pharma Mar, Madrid 28770, Spain

[4] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

[5] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(03)01551-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of variolin B from 4-methoxy-7-azaindole is described. The preparation of the protected amino derivative 10 and a coupling reaction of the iodo derivative 12 with 2-acetylamino-4-trimethylstannylpyrimidine are the key steps of the sequence. The use of N-tosyldichloromethanimine for the cyclisation step afforded a good entry to the 9-aminopyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine system. Variolin B was obtained from the triply protected tetracyclic compound 13 in two steps. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：6191 / 6194

页数：4

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