Total synthesis of variolin B

被引:45
作者
Anderson, RJ [1 ]
Morris, JC [1 ]
机构
[1] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand
关键词
D O I
10.1016/S0040-4039(01)01881-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The total synthesis of the marine alkaloid variolin B has been achieved in eight steps, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:8697 / 8699
页数:3
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