Novel FKS Mutations Associated with Echinocandin Resistance in Candida Species

被引：82

作者：

Garcia-Effron, Guillermo ^{[2
]}

Chua, Daniel Joseph ^{[1
]}

Tomada, Jon Rupert ^{[1
]}

DiPersio, Joseph ^{[1
]}

Perlin, David S. ^{[2
]}

Ghannoum, Mahmoud ^{[3
]}

Bonilla, Hector ^{[1
]}

机构：

[1] Summa Hlth Syst, Akron, OH 44305 USA

[2] Publ Hlth Res Inst, Newark, NJ USA

[3] Case Western Reserve Univ Hosp, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期

关键词：

CASPOFUNGIN RESISTANCE; REDUCED SUSCEPTIBILITY; INVASIVE CANDIDIASIS; KRUSEI ISOLATE; ANIDULAFUNGIN; EMERGENCE; ALBICANS; PARAPSILOSIS; FLUCONAZOLE; SECONDARY;

D O I：

10.1128/AAC.00998-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis. The first isolate emerged during echinocandin treatment, while the others emerged after the same treatment. These strains harbored an amino acid substitution in Fksp never linked before with reduced echinocandin susceptibility in C. tropicalis or in C. glabrata. The molecular mechanism of reduced susceptibility was confirmed using a 1,3-beta-D-glucan synthase inhibition assay.

引用

页码：2225 / 2227

页数：3

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