Fabrication of multicolor-encoded microspheres by tagging semiconductor nanocrystals to hydrogel spheres

被引：166

作者：

Kuang, M

Wang, DY ^{[1
]}

Bao, HB

Gao, MY

Möhwald, H

Jiang, M

机构：

[1] Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany

[2] Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China

[3] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 03期

关键词：

D O I：

10.1002/adma.200400818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single- or multicolor-encoded microspheres are created by confining water-soluble CdTe nanocrystals with different sizes within hydrogel microspheres of N-isopropyl-acrylamide and 4-vinylpyridine copolymer based on the pH-responsive swelling behavior of the get (see Figure). The emission intensity level and color of the resulting fluorescent spheres can be manipulated simply by changing the concentrations of the different-sized NCs and their molar ratios.

引用

收藏

页码：267 / +

页数：5

相关论文

共 27 条

[1] Less is more in medicine - Sophisticated forms of nanotechnology will find some of their first real-world applications in biomedical research, disease diagnosis and, possibly, therapy [J].

Alivisatos, AP .

SCIENTIFIC AMERICAN, 2001, 285 (03) :66-73

[2] Semiconductor clusters, nanocrystals, and quantum dots [J].

Alivisatos, AP .

SCIENCE, 1996, 271 (5251) :933-937

[3] Optical barcoding of colloidal suspensions: applications in genomics, proteomics and drug discovery [J].

Battersby, BJ ;

Lawrie, GA ;

Johnston, APR ;

Trau, M .

CHEMICAL COMMUNICATIONS, 2002, (14) :1435-1441

[4] Toward larger chemical libraries: Encoding with fluorescent colloids in combinatorial chemistry [J].

Battersby, BJ ;

Bryant, D ;

Meutermans, W ;

Matthews, D ;

Smythe, ML ;

Trau, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (09) :2138-2139

[5] A comparison of the swelling behaviour of copolymer and interpenetrating network microgel particles [J].

Bouillot, P ;

Vincent, B .

COLLOID AND POLYMER SCIENCE, 2000, 278 (01) :74-79

[6] Semiconductor nanocrystals as fluorescent biological labels [J].

Bruchez, M ;

Moronne, M ;

Gin, P ;

Weiss, S ;

Alivisatos, AP .

SCIENCE, 1998, 281 (5385) :2013-2016

[7]

CHAN WC, 1998, NANO LETT, V281, P2015

[8] Luminescent quantum dots for multiplexed biological detection and imaging [J].

Chan, WCW ;

Maxwell, DJ ;

Gao, XH ;

Bailey, RE ;

Han, MY ;

Nie, SM .

CURRENT OPINION IN BIOTECHNOLOGY, 2002, 13 (01) :40-46

[9]

Fulton RJ, 1997, CLIN CHEM, V43, P1749

[10] Strongly photoluminescent CdTe nanocrystals by proper surface modification [J].

Gao, MY ;

Kirstein, S ;

Möhwald, H ;

Rogach, AL ;

Kornowski, A ;

Eychmüller, A ;

Weller, H .

JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (43) :8360-8363