Peptidoglycan recognition proteins of the innate immune system

被引：125

作者：

Guan, Rongjin

Mariuzza, Roy A. ^{[1
]}

机构：

[1] Univ Maryland, Inst Biotechnol, Ctr Adv Res Biotechnol, WM Keck Lab Struct Biol, Rockville, MD 20850 USA

[2] NIDDK, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN MICROBIOLOGY | 2007年 / 15卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tim.2007.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptidoglycan (PGN) is the major component of bacterial cell walls and one of the main microbial products recognized by the innate immune system. PGN recognition is mediated by several families of pattern recognition molecules, including Toll-like receptors, nucleotide-binding oligomerization domain-containing proteins, and peptidoglycan recognition proteins (PGRPs). However, only the interaction of PGN with PGRPs, which are highly conserved from insects to mammals, has so far been characterized at the molecular level. Here, we describe recent structural studies of PGRPs that reveal the basis for PGN recognition and provide insights into the signal transduction and antibacterial activities of these innate immune proteins.

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页码：127 / 134

页数：8

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