Facile preparation of chiral P,N-hydrazone ligands and their Pd-catalyzed asymmetric allylic alkylations

被引：13

作者：

Mino, T ^{[1
]}

Komatsumoto, E ^{[1
]}

Nakadai, S ^{[1
]}

Toyoda, H ^{[1
]}

Sakamoto, M ^{[1
]}

Fujita, T ^{[1
]}

机构：

[1] Chiba Univ, Fac Engn, Dept Mat Technol, Inage Ku, Chiba 2638522, Japan

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2003年 / 196卷 / 1-2期

关键词：

enantioselective; allylic alkylation; palladium; chiral hydrazone; phosphanylation; PLANAR CHIRALITY; SUBSTITUTION; COMPLEXES; ENANTIOSELECTIVITY; HYDRAZONES; PYRIDINE;

D O I：

10.1016/S1381-1169(02)00630-1

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Chiral hydrazone ligands 2 are easily accessible in good yields by nucleophilic phosphanylation of corresponding orthofluorobenzaldehyde SAMP hydrazone derivatives with KPPh2. Palladium-catalyzed asymmetric allylic alkylation of 1,3diphenyl-2-propenyl acetate (6) with a dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of chiral hydrazone ligands 2g in high yields with high enantioselectivities. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：13 / 20

页数：8

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