Facile asymmetric synthesis of the core nuclei of xanthanolides, guaianolides, and eudesmanolides

被引：73

作者：

Nosse, B ^{[1
]}

Chhor, RB ^{[1
]}

Jeong, WB ^{[1
]}

Bohm, C ^{[1
]}

Reiser, O ^{[1
]}

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93053 Regensburg, Germany

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 06期

关键词：

D O I：

10.1021/ol034141s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bicylic and tricyclic gamma-butyrolactones with 5,7-, 5,6,5-, 5,6,6-, or 5,7,5-fused ring systems, being found in xanthanolides, eudesmanolides, and guaianolides, were readily synthesized from methyl furan-2-carboxylic acid. Key steps were a copper(I)-catalyzed asymmetric cyclopropanation, Sakurai allylations, intramolecular ene reactions, and ring-closing metathesis reactions.

引用

页码：941 / 944

页数：4

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