Apoptosis: Mitochondrial membrane permeabilization - The (W)hole story?

被引：146

作者：

Zamzami, N ^{[1
]}

Kroemer, G ^{[1
]}

机构：

[1] Inst Gustave Roussy, CNRS, UMR 1599, F-94805 Villejuif, France

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(02)01433-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One critical step of apoptosis is the release of mitochondrial proteins through the outer mitochondrial membrane. Recent work shows that two pro-apoptotic Bcl-2 family proteins, Bax and Bid, as well as the mitochondrion-specific lipid cardiolipin may cooperate in chemically defined liposomes to generate a protein-permeable conduit, relaunching the debate an the identity of the pore responsible for mitochondrial membrane permeabilization during apoptosis.

引用

页码：R71 / R73

页数：3

共 20 条

[1] Mitochondrial apoptosis and the peripheral benzodiazepine receptor: A novel target for viral and pharmacological manipulation [J].

Castedo, M ;

Perfettini, JL ;

Kroemer, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (09) :1121-1125

[2] Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane [J].

Eskes, R ;

Desagher, S ;

Antonsson, B ;

Martinou, JC .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (03) :929-935

[3] Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity [J].

Esposti, MD ;

Erler, JT ;

Hickman, JA ;

Dive, C .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (21) :7268-7276

[4]

Fernandez MG, 2002, CELL GROWTH DIFFER, V13, P449

[5] Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax [J].

Gogvadze, V ;

Robertson, JD ;

Zhivotovsky, B ;

Orrenius, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (22) :19066-19071

[6] Mitochondrial control of cell death [J].

Kroemer, G ;

Reed, JC .

NATURE MEDICINE, 2000, 6 (05) :513-519

[7] Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane [J].

Kuwana, T ;

Mackey, MR ;

Perkins, G ;

Ellisman, MH ;

Latterich, M ;

Schneiter, R ;

Green, DR ;

Newmeyer, DD .

CELL, 2002, 111 (03) :331-342

[8] Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics [J].

Letai, A ;

Bassik, MC ;

Walensky, LD ;

Sorcinelli, MD ;

Weiler, S ;

Korsmeyer, SJ .

CANCER CELL, 2002, 2 (03) :183-192

[9] Cardiolipin provides specificity for targeting of tBid to mitochondria [J].

Lutter, M ;

Fang, M ;

Luo, X ;

Nishijima, M ;

Xie, XS ;

Wang, XD .

NATURE CELL BIOLOGY, 2000, 2 (10) :754-756

[10] Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis [J].

Marzo, I ;

Brenner, C ;

Zamzami, N ;

Jürgensmeier, JM ;

Susin, SA ;

Vieira, HLA ;

Prévost, MC ;

Xie, ZH ;

Matsuyama, S ;

Reed, JC ;

Kroemer, G .

SCIENCE, 1998, 281 (5385) :2027-2031

← 1 2 →