Long-term modulation of presynaptic 5-HT-output:: experimentally induced changes in cortical 5-HT-transporter density, tryptophan hydroxylase content and 5-HT innervation density

被引：37

作者：

Huether, G ^{[1
]}

Zhou, D ^{[1
]}

Rüther, E ^{[1
]}

机构：

[1] Univ Gottingen, Psychiat Clin, D-37075 Gottingen, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 1997年 / 104卷 / 10期

关键词：

H-3]-paroxetine-binding; tryptophan hydroxylase; serotonin (5-HT); 5-HT transporter; 5-HT innervation; food restriction; bulbectomy; amphetamines; antidepressants; presynaptic regulation;

D O I：

10.1007/BF01273313

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Whereas experimentally induced long-term changes of postsynaptic mechanisms of 5-HT neurotransmission have been studied in great detail, much less is currently known about the effects of certain treatments on the presynaptic components governing the output of 5-HT in individual brain regions. This contribution summarizes the results of a series of experiments on the influence of different physiologic and pharmacologic manipulations on three different parameters of 5-HT presynapses, 5-HT transporter density, tryptophan hydroxylase content, and serotonin level in the rat frontal cortex. The combined measurement of several parameters of 5-HT presynapses allows to differentiate between treatments which exclusively affect the density of 5-HT transporters (long-term food restriction), which exclusively affect the level of tryptophan hydroxylase apoenzyme (imipramine treatment of olfactory bulbectomized rats) or which cause a parallel increase (bulbectomy, chronic administration of tranylcypramine to rats with chemical lesions of their cortical 5-HT innervation) or a parallel decrease (administration of p-chloroamphetamine) of both parameters, indicating treatment-induced changes in the density of 5-HT presynapses in the frontal cortex. Each of these changes may lead to an altered output of serotonergic afferences, and may therefore act to either potentiate or to attenuate the impact of serotonin-mediated effects on the activity of local networks located in a certain brain region.

引用

页码：993 / 1004

页数：12

共 38 条

[21] Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex [J].

Huether, G ;

Zhou, D ;

Schmidt, S ;

Wiltfang, J ;

Ruther, E .

BIOLOGICAL PSYCHIATRY, 1997, 41 (12) :1174-1180

[22] THE METABOLIC-FATE OF INFUSED L-TRYPTOPHAN IN MEN - POSSIBLE CLINICAL IMPLICATIONS OF THE ACCUMULATION OF CIRCULATING TRYPTOPHAN AND TRYPTOPHAN-METABOLITES [J].

HUETHER, G ;

HAJAK, G ;

REIMER, A ;

POEGGELER, B ;

BLOMER, M ;

RODENBECK, A ;

RUTHER, E .

PSYCHOPHARMACOLOGY, 1992, 109 (04) :422-432

[23] The central adaptation syndrome: Psychosocial stress as a trigger for adaptive modifications of brain structure and brain function [J].

Huether, G .

PROGRESS IN NEUROBIOLOGY, 1996, 48 (06) :569-612

[24]

KUHN DM, 1980, J BIOL CHEM, V255, P4137

[25] IMAGING OF SEROTONIN AND DOPAMINE TRANSPORTERS IN THE LIVING HUMAN BRAIN [J].

KUIKKA, JT ;

TIIHONEN, J ;

BERGSTROM, KA ;

KARHU, J ;

HARTIKAINEN, P ;

VIINAMAKI, H ;

LANSIMIES, E ;

LEHTONEN, J ;

HAKOLA, P .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1995, 22 (04) :346-350

[26] REGIONAL BRAIN EXPRESSION OF SEROTONIN TRANSPORTER MESSENGER-RNA AND ITS REGULATION BY REUPTAKE INHIBITING ANTIDEPRESSANTS [J].

LESCH, KP ;

AULAKH, CS ;

WOLOZIN, BL ;

TOLLIVER, TJ ;

HILL, JL ;

MURPHY, DL .

MOLECULAR BRAIN RESEARCH, 1993, 17 (1-2) :31-35

[27]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[28] ANTIDEPRESSANTS INDUCE REGENERATION OF CATECHOLAMINERGIC AXON TERMINALS IN THE RAT CEREBRAL-CORTEX [J].

NAKAMURA, S .

NEUROSCIENCE LETTERS, 1990, 111 (1-2) :64-68

[29] EFFECTS OF MIANSERIN AND FLUOXETINE ON AXONAL REGENERATION OF BRAIN CATECHOLAMINE NEURONS [J].

NAKAMURA, S .

NEUROREPORT, 1991, 2 (09) :525-528

[30] EFFECT OF CHRONIC ADMINISTRATION OF THE 6-AZA ANALOG OF MIANSERIN (ORG 3770) AND ITS ENANTIOMERS ON BEHAVIOR AND CHANGES IN NORADRENALINE METABOLISM OF OLFACTORY-BULBECTOMIZED RATS IN THE OPEN-FIELD APPARATUS [J].

OCONNOR, WT ;

LEONARD, BE .

NEUROPHARMACOLOGY, 1986, 25 (03) :267-270

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