Hallmarks of cancer: Interactions with the tumor stroma

被引：860

作者：

Pietras, Kristian ^{[1
]}

Ostman, Arne ^{[2
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Div Vasc Biol, SE-17177 Stockholm, Sweden

[2] Karolinska Univ Sjukhuset, Karolinska Inst, Dept Oncol Pathol, SE-17176 Stockholm, Sweden

来源：

EXPERIMENTAL CELL RESEARCH | 2010年 / 316卷 / 08期

基金：

瑞典研究理事会;

关键词：

Cancer; Tumor stroma; Cancer-associated fibroblast; Pericyte; Targeted therapy; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR; BREAST-CANCER; PERIVASCULAR NICHE; PANCREATIC-CANCER; MOUSE MODEL; IN-VIVO; FIBROBLASTS; PDGF; ANGIOGENESIS;

D O I：

10.1016/j.yexcr.2010.02.045

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ten years ago, Hanahan and Weinberg delineated six "Hallmarks of cancer" which summarize several decades of intense cancer research. However, tumor cells do not act in isolation, but rather subsist in a rich microenvironment provided by resident fibroblasts, endothelial cells, pericytes, leukocytes, and extra-cellular matrix. It is increasingly appreciated that the tumor stroma is an integral part of cancer initiation, growth and progression. The stromal elements of tumors hold prognostic, as well as response-predictive, information, and abundant targeting opportunities within the tumor microenvironment are continually identified. Herein we review the current understanding of tumor cell interactions with the tumor stroma with a particular focus on cancer-associated fibroblasts and pericytes. Moreover, we discuss emerging fields of research which need to be further explored in order to fulfil the promise of stroma-targeted therapies for cancer. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1324 / 1331

页数：8

共 72 条

[31] Host stromal bradykinin B2 receptor signaling facilitates tumor-associated angiogenesis and tumor growth [J].

Ikeda, Y ;

Hayashi, I ;

Kamoshita, E ;

Yamazaki, A ;

Endo, H ;

Ishihara, K ;

Yamashina, S ;

Tsutsumi, Y ;

Matsubara, H ;

Majima, M .

CANCER RESEARCH, 2004, 64 (15) :5178-5185

[32] Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma [J].

Infante, Jeffrey R. ;

Matsubayashi, Hiroyuki ;

Sato, Norihiro ;

Tonascia, James ;

Klein, Alison P. ;

Riall, Taylor A. ;

Yeo, Charles ;

Iacobuzio-Donahue, Christine ;

Goggins, Michael .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (03) :319-325

[33] In situ detection of phosphorylated platelet-derived growth factor receptor β using a generalized proximity ligation method [J].

Jarvius, Malin ;

Paulsson, Janna ;

Weibrecht, Irene ;

Leuchowius, Karl-Johan ;

Andersson, Ann-Catrin ;

Wahlby, Carolina ;

Gullberg, Mats ;

Botling, Johan ;

Sjoblom, Tobias ;

Markova, Boyka ;

Ostman, Arne ;

Landegren, Ulf ;

Soderberg, Ola .

MOLECULAR & CELLULAR PROTEOMICS, 2007, 6 (09) :1500-1509

[34] Microenvironmental regulation of metastasis [J].

Joyce, Johanna A. ;

Pollard, Jeffrey W. .

NATURE REVIEWS CANCER, 2009, 9 (04) :239-252

[35] Fibroblasts in cancer [J].

Kalluri, R ;

Zeisberg, M .

NATURE REVIEWS CANCER, 2006, 6 (05) :392-401

[36] VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche [J].

Kaplan, RN ;

Riba, RD ;

Zacharoulis, S ;

Bramley, AH ;

Vincent, L ;

Costa, C ;

MacDonald, DD ;

Jin, DK ;

Shido, K ;

Kerns, SA ;

Zhu, ZP ;

Hicklin, D ;

Wu, Y ;

Port, JL ;

Altorki, N ;

Port, ER ;

Ruggero, D ;

Shmelkov, SV ;

Jensen, KK ;

Rafii, S ;

Lyden, D .

NATURE, 2005, 438 (7069) :820-827

[37] Mesenchymal stem cells within tumour stroma promote breast cancer metastasis [J].

Karnoub, Antoine E. ;

Dash, Ajeeta B. ;

Vo, Annie P. ;

Sullivan, Andrew ;

Brooks, Mary W. ;

Bell, George W. ;

Richardson, Andrea L. ;

Polyak, Kornelia ;

Tubo, Ross ;

Weinberg, Robert A. .

NATURE, 2007, 449 (7162) :557-U4

[38] Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis [J].

Kiaris, H ;

Chatzistamou, L ;

Trimis, G ;

Frangou-Plemmenou, M ;

Pafiti-Kondi, A ;

Kalofoutis, A .

CANCER RESEARCH, 2005, 65 (05) :1627-1630

[39] Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF [J].

LeBedis, C ;

Chen, KG ;

Fallavollita, L ;

Boutros, T ;

Brodt, P .

INTERNATIONAL JOURNAL OF CANCER, 2002, 100 (01) :2-8

[40] Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling [J].

Levental, Kandice R. ;

Yu, Hongmei ;

Kass, Laura ;

Lakins, Johnathon N. ;

Egeblad, Mikala ;

Erler, Janine T. ;

Fong, Sheri F. T. ;

Csiszar, Katalin ;

Giaccia, Amato ;

Weninger, Wolfgang ;

Yamauchi, Mitsuo ;

Gasser, David L. ;

Weaver, Valerie M. .

CELL, 2009, 139 (05) :891-906

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