MYCN oncoprotein targets and their therapeutic potential

被引：90

作者：

Bell, Emma ^{[1
]}

Chen, Lindi ^{[1
]}

Liu, Tao ^{[2
]}

Marshall, Glenn M. ^{[2
]}

Lunec, John ^{[1
]}

Tweddle, Deborah A. ^{[1
]}

机构：

[1] Newcastle Univ, No Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Childrens Canc Inst Australia, Sydney, NSW, Australia

来源：

CANCER LETTERS | 2010年 / 293卷 / 02期

基金：

英国医学研究理事会;

关键词：

MYCN; Microarrays; Neuroblastoma; Target genes; HUMAN NEUROBLASTOMA-CELLS; DIRECT TRANSCRIPTIONAL TARGET; DEACETYLASE INHIBITOR BL1521; PEPTIDE NUCLEIC-ACID; ARF TUMOR-SUPPRESSOR; MRP GENE-EXPRESSION; N-MYC; C-MYC; ORNITHINE-DECARBOXYLASE; CENTROSOME AMPLIFICATION;

D O I：

10.1016/j.canlet.2010.01.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The MYCN oncogene encodes a transcription factor which is amplified in up to 40% of high risk neuroblastomas. MYCN amplification is a well-established poor prognostic marker in neuroblastoma, however the role of MYCN expression and the mechanisms by which it acts to promote an aggressive phenotype remain largely unknown. This review discusses the current evidence identifying the direct and indirect downstream transcriptional targets of MYCN from recent studies, with particular reference to how MYCN affects the cell cycle, DNA damage response, differentiation and apoptosis in neuroblastoma. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：144 / 157

页数：14

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