Synthesis of 5-phosphate-D-arabinohydroxamic acid, a potent transition state analogue inhibitor of 6-phosphate-D-glucose isomerases

被引：5

作者：

Bonnette, C ^{[1
]}

Salmon, L ^{[1
]}

Gaudemer, A ^{[1
]}

机构：

[1] UNIV PARIS 11,INST CHIM MOLEC ORSAY,CNRS,LAB CHIM BIOORGAN & BIOINORGAN,F-91405 ORSAY,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 08期

关键词：

D O I：

10.1016/0040-4039(96)00004-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first hydroxamate-based and potent transition slate analogue (TSA) inhibitor of 6-phosphate-D-glucose isomerases, 5-phosphate-D-anbinohydroxamic acid 3, has been synthesized by conversion of D-arabinose to a protected derivative of 5-phosphate-D-arabinonic acid and introduction of the hydroxamate group by coupling with O-benzylhydroxylamine.

引用

页码：1221 / 1224

页数：4

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