Emerging themes in medicinal glycoscience

被引:139
作者
Koeller, KM
Wong, CH
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
关键词
glycoconjugate; synthesis; therapeutic; antibiotic; vaccine;
D O I
10.1038/78435
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The recognition of complex carbohydrates and glycoconjugates as mediators of important biological processes has stimulated investigation into their therapeutic potential. New approaches for the simplification of glycoconjugate synthesis are overcoming the limitations of existing methods and providing a diverse array of these biomolecules. As the accessibility of glycoconjugates increases, carbohydrate-based constructs are becoming available for analysis as medicinal agents in a wide range of therapies.
引用
收藏
页码:835 / 841
页数:7
相关论文
共 117 条
[21]   Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala [J].
Ge, M ;
Chen, Z ;
Onishi, HR ;
Kohler, J ;
Silver, LL ;
Kerns, R ;
Fukuzawa, S ;
Thompson, C ;
Kahne, D .
SCIENCE, 1999, 284 (5413) :507-511
[22]   GLYCOPROTEIN GLYCANS - ROLES AND CONTROLS [J].
GEISOW, MJ .
TRENDS IN BIOTECHNOLOGY, 1992, 10 (10) :333-335
[23]  
Gewehr M, 1997, SYNTHESIS-STUTTGART, P1499
[24]   Recent advances in the chemoenzymatic synthesis of carbohydrates and carbohydrate mimetics [J].
Gijsen, HJM ;
Qiao, L ;
Fitz, W ;
Wong, CH .
CHEMICAL REVIEWS, 1996, 96 (01) :443-473
[25]   Synthetic ligands point to cell surface strategies [J].
Gordon, EJ ;
Sanders, WJ ;
Kiessling, LL .
NATURE, 1998, 392 (6671) :30-31
[26]   Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation [J].
Greenberg, WA ;
Priestley, ES ;
Sears, PS ;
Alper, PB ;
Rosenbohm, C ;
Hendrix, M ;
Hung, SC ;
Wong, CH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (28) :6527-6541
[27]   An antibiotic cloaked by its own resistance enzyme [J].
Haddad, J ;
Vakulenko, S ;
Mobashery, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (50) :11922-11923
[28]   Glycosphingolipid antigens and cancer therapy [J].
Hakomori, S ;
Zhang, YM .
CHEMISTRY & BIOLOGY, 1997, 4 (02) :97-104
[29]   SOLUTION-PHASE AND SOLID-PHASE SYNTHESIS OF INHIBITORS OF HELICOBACTER-PYLORI ATTACHMENT AND E-SELECTIN-MEDIATED LEUKOCYTE ADHESION [J].
HALCOMB, RL ;
HUANG, HM ;
WONG, CH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (25) :11315-11322
[30]   A NEW CLASS OF SYNTHETIC ANTIBACTERIALS ACTING ON LIPOPOLYSACCHARIDE BIOSYNTHESIS [J].
HAMMOND, SM ;
CLAESSON, A ;
JANSSON, AM ;
LARSSON, LG ;
PRING, BG ;
TOWN, CM ;
EKSTROM, B .
NATURE, 1987, 327 (6124) :730-732